Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 7/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HRAS | P01112 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407500 | 0.89 | MAPT (0.50) | ARPGRCYP3A4ABCC9ABCC8 | |
| SCHEMBL8407298 | 0.87 | AR (0.76) | ARPGRCYP3A4LMNAMAPK1 | |
| SCHEMBL10975838 | 0.83 | ABCC9 (0.64) | ARPGRCYP3A4ABCC9ABCC8 | |
| SCHEMBL8409262 | 0.82 | AR (0.67) | ARPGRCYP3A4ABCC9ABCC8 | |
| SCHEMBL8408906 | 0.81 | AR (0.72) | ARPGRCYP3A4LMNAMAPK1 | |
| SCHEMBL8407297 | 0.81 | AR (0.72) | ARPGRCYP3A4LMNAMAPK1 | |
| SCHEMBL8407131 | 0.80 | AR (0.53) | ARPGRCYP3A4ABCC9ABCC8 | |
| SCHEMBL8407302 | 0.80 | MAPT (0.51) | MEN1LMNAMAPTXBP1MAPK1 | |
| SCHEMBL10421023 | 0.79 | AR (0.52) | ARPGRCYP3A4ABCC9ABCC8 | |
| SCHEMBL8407474 | 0.78 | AR (0.68) | ARPGRCYP3A4LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040932-B1 | AMIDE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-03 | — | — | EP | claimed |
| US-4386080-A | 3,4-DISUBSTITUTED-N-ACYLANILINES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1983-05-31 | — | — | US | claimed |
| EP-0040932-A1 | Amide derivatives, process for their manufacture and pharmaceutical or veterinary compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-12-02 | — | — | EP | claimed |
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0040932-B1 | AMIDE DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL OR VETERINARY COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-03 | — | — | EP | disclosed |
| US-4386080-A | 3,4-DISUBSTITUTED-N-ACYLANILINES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1983-05-31 | — | — | US | disclosed |
| EP-0040932-A1 | Amide derivatives, process for their manufacture and pharmaceutical or veterinary compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-12-02 | — | — | EP | disclosed |