Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Forodesine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Forodesine SCHEMBL15740230 | 1.00 | PNP (0.75) | PNPMTAP | |
| Forodesine SCHEMBL8244721 | 1.00 | PNP (0.75) | PNPMTAP | |
| Forodesine SCHEMBL506383 | 1.00 | PNP (0.75) | PNPMTAP | |
| Forodesine SCHEMBL1949526 | 0.99 | PNP (0.73) | PNPMTAP | |
| Hydrochloric Acid SCHEMBL4837679 | 0.87 | PNP (0.63) | PNPMTAP | |
| Galidesivir SCHEMBL23102311 | 0.86 | PNP (1.00) | PNPMTAP | |
| Galidesivir SCHEMBL15717852 | 0.86 | PNP (1.00) | PNPMTAP | |
| Galidesivir SCHEMBL12468816 | 0.86 | PNP (1.00) | PNPMTAP | |
| Galidesivir SCHEMBL15718263 | 0.86 | PNP (1.00) | PNPMTAP | |
| Galidesivir SCHEMBL25424734 | 0.86 | PNP (1.00) | PNPMTAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985848-A | EFFECTIVE INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE AND/OR NUCLEOSIDE HYDROLASES; TREATMENT AND/OR PROPHYLAXIS OF A PROTOZOAN INFECTION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 1999-11-16 | — | — | US | disclosed |