Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 7/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.51 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.50 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.50 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.50 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.50 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | S100B | P04271 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409575 | 1.00 | PRSS1 (0.54) | PRSS1PRSS2PRSS3POLBTMPRSS2 | |
| SCHEMBL7283709 | 0.88 | ITGB3 (0.52) | PRSS1PRSS2PRSS3POLBTMPRSS2 | |
| SCHEMBL7721357 | 0.87 | PRSS1 (0.56) | PRSS1PRSS2PRSS3POLBF2 | |
| SCHEMBL8378203 | 0.86 | PRSS1 (0.49) | PRSS1PRSS2PRSS3POLBTMPRSS2 | |
| SCHEMBL8410164 | 0.85 | PRSS1 (0.58) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| Hydrochloric Acid SCHEMBL8887198 | 0.83 | ITGB3 (0.61) | PRSS1PRSS2PRSS3POLBMAPT | |
| SCHEMBL8407198 | 0.83 | ITGB3 (0.69) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| SCHEMBL8410645 | 0.83 | ITGB3 (0.69) | PRSS1PRSS2PRSS3TMPRSS2PRMT1 | |
| SCHEMBL7292847 | 0.83 | ITGB3 (0.56) | PRSS1PRSS2PRSS3POLBTMPRSS2 | |
| SCHEMBL7344446 | 0.82 | PLAU (0.54) | PRSS1POLBTMPRSS2F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |