Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 12/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841346 | 0.90 | AGTR1 (0.45) | AGTR1LTB4R2ABCB11GP6MME | |
| SCHEMBL840125 | 0.90 | AGTR1 (0.45) | AGTR1LTB4R2ABCB11GP6MME | |
| SCHEMBL839083 | 0.88 | AGTR1 (0.45) | AGTR1LTB4R2ABCB11GP6MME | |
| SCHEMBL840839 | 0.86 | AGTR1 (0.44) | AGTR1LTB4R2ABCB11GP6MME | |
| SCHEMBL839725 | 0.85 | AGTR1 (0.44) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL859394 | 0.85 | AGTR1 (0.41) | AGTR1LTB4R2ABCB11GP6MME | |
| SCHEMBL839949 | 0.85 | AGTR1 (0.41) | AGTR1LTB4R2ABCB11GP6MME | |
| SCHEMBL839252 | 0.85 | AGTR1 (0.41) | AGTR1LTB4R2ABCB11GP6MME | |
| SCHEMBL839983 | 0.84 | AGTR1 (0.43) | AGTR1LTB4R2ABCB11GP6AGTR2 | |
| SCHEMBL840159 | 0.84 | AGTR1 (0.45) | AGTR1LTB4R2ABCB11GP6AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143298-B2 | Dual-acting antihypertensive agents | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |