Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568208 | 0.85 | SCN1A (0.44) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL9568210 | 0.85 | SCN1A (0.44) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL9185970 | 0.85 | MEN1 (0.54) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8410586 | 0.84 | MEN1 (0.52) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL8949258 | 0.79 | CNR2 (0.41) | SMN1; SMN2RAB9AMEN1KMT2AHPGD | |
| SCHEMBL8949056 | 0.79 | CNR2 (0.41) | SMN1; SMN2RAB9AMEN1KMT2AHPGD | |
| SCHEMBL8409339 | 0.79 | NPC1 (0.61) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL9174248 | 0.78 | MAPT (0.48) | SMN1; SMN2MEN1KMT2ASMYD3HPGD | |
| SCHEMBL15498625 | 0.77 | MEN1 (0.59) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL15510848 | 0.77 | MEN1 (0.59) | SMN1; SMN2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |