SCHEMBL8408089

SCHEMBL8408089

COC(=O)C1CCC(C2CCC(=O)CC2)CC1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.44
BRD4 O60885 1/20 0.41
CHRNB2 P17787 1/20 0.40
CHRNB4 P30926 1/20 0.40
CHRNA3 P32297 1/20 0.40
CHRNA7 P36544 1/20 0.40
CHRNA4 P43681 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
PKM P14618 1/20 0.38
ALDH1A1 P00352 2/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HSD17B10 Q99714 1/20 0.37
POLB P06746 1/20 0.36
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8408087 1.00 TP53 (0.44) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL8410901 1.00 TP53 (0.44) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL8410904 1.00 TP53 (0.44) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL791232 0.88 BRD4 (0.46) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL25953781 0.85 TP53 (0.55) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL22657540 0.85 TP53 (0.55) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL4547605 0.85 TP53 (0.55) TP53BRD4CHRNB2CHRNB4CHRNA3
Ethylene SCHEMBL11701928 0.84 BRD4 (0.43) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL9633492 0.81 SMN1; SMN2 (0.46) TP53BRD4CHRNB2CHRNB4CHRNA3
SCHEMBL13245966 0.80 BRD4 (0.38) TP53BRD4CHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023193789-A1 WEE1 DEGRADING COMPOUNDS BEIJING NEOX BIOTECH LIMITED (CN) 2023-10-12 WO disclosed
US-5989452-A LIQUID CRYSTAL MIXTURE HAVING HEAT RESISTANCE, LOW TEMPERATURE SOLUBILITY; DISPLAYS CHISSO CORPORATION (JP) 1999-11-23 US disclosed
EP-0884296-A1 FLUOROALKENYL DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS CHISSO CORPORATION (JP) 1998-12-16 EP disclosed