Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 8/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | DRD3 | P35462 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20610512 | 0.95 | ADRA1A (0.79) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL20610682 | 0.94 | ADRA1A (0.81) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL8408731 | 0.91 | ADRA1A (0.74) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL20610508 | 0.90 | ADRA1A (0.81) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL9832332 | 0.89 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL7824819 | 0.89 | ADRA1A (0.76) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| Bromide SCHEMBL7833561 | 0.88 | ADRA1A (0.75) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL20631454 | 0.88 | ADRA1A (0.92) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL7826177 | 0.87 | ADRA1A (0.79) | ADRA1AADRA1BADRA1DADRA2AADRA2B | |
| SCHEMBL10623369 | 0.86 | ADRA1A (0.78) | ADRA1AADRA1BADRA1DADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869484-A | TREATING DISEASES DERIVED BY ACETYLCHOLINE DEFICIENCY; ALZHEIMER*S DISEASE | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1999-02-09 | — | — | US | disclosed |
| EP-0772608-A1 | PHENYLCARBAMATE DERIVATIVES SUITABLE TO THE USE AS ANTICHOLINESTERASE SUBSTANCES | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002524-A1 | PHENYLCARBAMATE DERIVATIVES SUITABLE TO THE USE AS ANTICHOLINESTERASE SUBSTANCES | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1996-02-01 | — | — | WO | disclosed |