Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | IL18 | Q14116 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886444 | 0.89 | CNR1 (0.53) | ALDH1A1CNR1KDM4ELMNAMAPT | |
| SCHEMBL4426853 | 0.83 | PPID (0.55) | ALDH1A1CNR1KDM4ELMNAMAPT | |
| SCHEMBL8410208 | 0.82 | MAPT (0.52) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL27519540 | 0.79 | ALDH1A1 (0.82) | ALDH1A1KDM4ELMNAMAPTMEN1 | |
| SCHEMBL7281233 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMAPK1MMP3 | |
| SCHEMBL14423993 | 0.79 | CNR1 (0.62) | ALDH1A1CNR1KDM4ELMNAMAPT | |
| SCHEMBL3929566 | 0.78 | MAPT (0.55) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL8573559 | 0.78 | CNR1 (0.61) | ALDH1A1CNR1KDM4ELMNAMAPT | |
| SCHEMBL7389737 | 0.77 | CNR1 (0.60) | ALDH1A1CNR1KDM4ELMNAMAPT | |
| SCHEMBL9937346 | 0.77 | ALDH1A1 (0.59) | ALDH1A1CNR1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922763-A | ANTICOAGULANT; CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1999-07-13 | — | — | US | disclosed |
| US-5736559-A | CARDIOVASCULAR DISORDERS; RESPIRATORY SYSTEM DISORDERS | KARL THOMAE GMBH (DE) | 1998-04-07 | — | — | US | disclosed |
| US-5597825-A | AGGREGATION INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1997-01-28 | — | — | US | disclosed |
| EP-0496378-B1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | THOMAE GMBH DR K (DE) | 1995-09-20 | — | — | EP | disclosed |
| EP-0496378-A1 | Biphenylderivatives, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-07-29 | — | — | EP | disclosed |