SCHEMBL8409071

SCHEMBL8409071

COc1ccc(C=CC(=O)C=Cc2ccc(N(C)C)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F3 P13726 2/20 0.77
HSD17B3 P37058 1/20 0.77
MAOB P27338 4/20 0.76
GPR183 P32249 1/20 0.64
MAOA P21397 2/20 0.63
MAPT P10636 2/20 0.63
MEN1 O00255 1/20 0.63
USP2 O75604 1/20 0.63
MAPK1 P28482 1/20 0.63
KMT2A Q03164 1/20 0.63
TLR9 Q9NR96 1/20 0.63
L3MBTL1 Q9Y468 1/20 0.63
GSK3B P49841 2/20 0.62
BACE1 P56817 1/20 0.62
STAT3 P40763 1/20 0.60
THRB P10828 1/20 0.60
ATM Q13315 1/20 0.60
HDAC3 O15379 1/20 0.57
HDAC1 Q13547 1/20 0.57
HDAC2 Q92769 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11143343 1.00 F3 (0.77) F3HSD17B3MAOBGPR183MAOA
SCHEMBL11328508 0.93 STAT3 (0.72) F3HSD17B3MAOBGPR183MAOA
SCHEMBL11328505 0.93 STAT3 (0.72) F3HSD17B3MAOBGPR183MAOA
SCHEMBL814395 0.88 HSD17B3 (1.00) F3HSD17B3MAOBMAOAMAPT
SCHEMBL3050207 0.88 HSD17B3 (1.00) F3HSD17B3MAOBMAOAMAPT
SCHEMBL814396 0.88 HSD17B3 (1.00) F3HSD17B3MAOBMAOAMAPT
SCHEMBL2744101 0.88 F3 (1.00) F3MAOBMAOAMAPTMEN1
SCHEMBL2744098 0.88 F3 (1.00) F3MAOBMAOAMAPTMEN1
SCHEMBL14331811 0.88 F3 (1.00) F3MAOBMAOAMAPTMEN1
SCHEMBL11525510 0.86 MAOB (1.00) F3MAOBMAOAMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0287818-A2 Polymerisable compounds and mixture containing them polymerisable by radiation HOECHST AKTIENGESELLSCHAFT (DE) 1988-10-26 EP claimed
US-4367280-A AROMATIC CARBONYL COMPOUND AND P-DIALKYLAMINO AROMATIC CARBONYL COMPOUND COMBINATION POLYMERIZATION INITIATOR FUJI PHOTO FILM CO., LTD. (JP) 1983-01-04 US claimed
US-4290870-A 5-ISOXOLONE, AROMATIC CARBONYL, DIALKYLAMINO AROMATIC CARBONYL OR FUJI PHOTO FILM CO., LTD. (JP) 1981-09-22 US claimed
US-4148658-A BENZOYLMETHYLENE-BENSOTHIAZOLYIDEND-THIAZOLIDONE COMPOUND, AMINE, AND AMINOARYLCARBONYL COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1979-04-10 US claimed
EP-0949540-B1 Method for producing lithographic printing plate suitable for laser scan exposure, and photopolymerizable composition FUJIFILM CORP (JP) 2012-05-02 EP disclosed
US-5922508-A CONSISTS OF A SUPPORT AND A PHOTOPOLYMERIZABLE LAYER CONTAINING A POLYMERIC BINDER, A POLYMERIZATION INITIATOR COMBINATION COMPRISING ATLEAST ONE PHOTOREDUCIBLE DYE AND ONE PHOTOINITIATOR, A FREE RADICAL POLYMERIZABLE ACRYLIC COMPOUND AGFA-GEVAERT AG (DE) 1999-07-13 US disclosed
EP-0507181-B1 Process for the fabrication of colour-proofs and light sensitive material therefor AGFA GEVAERT AG (DE) 1998-06-03 EP disclosed
EP-0354475-B1 Photopolymerisable image registration material HOECHST AG (DE) 1995-11-15 EP disclosed
EP-0359060-B1 Photopolymerisable mixture, recording material manufactured therefrom and process for the production of copies HOECHST AG (DE) 1994-11-09 EP disclosed
EP-0321827-B1 Photopolymerisable mixture and recording material manufactured therefrom HOECHST AG (DE) 1993-11-10 EP disclosed
EP-0321828-B1 Photopolymerisable mixture and recording material manufactured therefrom HOECHST AG (DE) 1993-11-10 EP disclosed
EP-0321826-B1 Photopolymerisable mixture and recording material manufactured therefrom HOECHST AG (DE) 1993-11-03 EP disclosed
EP-0321828-A2 Photopolymerisable mixture and recording material manufactured therefrom HOECHST AKTIENGESELLSCHAFT (DE) 1989-06-28 EP disclosed
EP-0321827-A2 Photopolymerisable mixture and recording material manufactured therefrom HOECHST AKTIENGESELLSCHAFT (DE) 1989-06-28 EP disclosed
EP-0321826-A2 Photopolymerisable mixture and recording material manufactured therefrom HOECHST AKTIENGESELLSCHAFT (DE) 1989-06-28 EP disclosed
US-4367280-A AROMATIC CARBONYL COMPOUND AND P-DIALKYLAMINO AROMATIC CARBONYL COMPOUND COMBINATION POLYMERIZATION INITIATOR FUJI PHOTO FILM CO., LTD. (JP) 1983-01-04 US disclosed
US-4290870-A 5-ISOXOLONE, AROMATIC CARBONYL, DIALKYLAMINO AROMATIC CARBONYL OR FUJI PHOTO FILM CO., LTD. (JP) 1981-09-22 US disclosed
US-4264710-A AN ETHYLENICALLY UNSATURATED COMPOUND, AND A PHOTOPOLYMERIZATION INIATOR FUJI PHOTO FILM CO., LTD. (JP) 1981-04-28 US disclosed
US-4259432-A HIGH SENSITIVITY TO ULTRAVIOLET RADIATION AND ARGON LASER RAYS FUJI PHOTO FILM CO., LTD. (JP) 1981-03-31 US disclosed
US-4148658-A BENZOYLMETHYLENE-BENSOTHIAZOLYIDEND-THIAZOLIDONE COMPOUND, AMINE, AND AMINOARYLCARBONYL COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1979-04-10 US disclosed