Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407479 | 0.87 | AR (0.63) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL8527587 | 0.84 | MAPT (0.64) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL8409965 | 0.84 | KDR (0.69) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL8410666 | 0.83 | EPHX1 (0.60) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL8410453 | 0.82 | AR (0.48) | HTTLMNAARPGRCYP3A4 | |
| SCHEMBL1431941 | 0.81 | EPHX1 (0.74) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL30977691 | 0.81 | EPHX1 (0.74) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL8410204 | 0.81 | EPHX1 (0.61) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL2705806 | 0.78 | MAPT (0.64) | MAPTHTTMEN1KMT2ANPSR1 | |
| SCHEMBL25894469 | 0.78 | MAPT (0.58) | MAPTHTTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |