Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8409970 | 0.85 | MDM4 (0.45) | MDM4TP53KMT2ASMN1; SMN2MLYCD | |
| SCHEMBL8407481 | 0.84 | MDM4 (0.44) | MDM4TP53KMT2ASMN1; SMN2THRA | |
| SCHEMBL8410454 | 0.83 | MDM4 (0.43) | MDM4TP53KMT2ASMN1; SMN2MLYCD | |
| SCHEMBL8410669 | 0.81 | KDM4E (0.42) | MDM4TP53KMT2ASMN1; SMN2THRA | |
| SCHEMBL8410205 | 0.79 | MDM4 (0.39) | MDM4TP53KMT2ASMN1; SMN2THRA | |
| SCHEMBL8407214 | 0.79 | ALDH1A1 (0.55) | MDM4TP53KMT2ASMN1; SMN2GAA | |
| SCHEMBL8407115 | 0.75 | MDM4 (0.44) | MDM4TP53KMT2ASMN1; SMN2MLYCD | |
| SCHEMBL14254814 | 0.71 | ALDH1A1 (0.64) | TP53SMN1; SMN2GAAALDH1A1KDM4E | |
| SCHEMBL8409003 | 0.70 | AR (0.55) | MDM4TP53KMT2ASMN1; SMN2GAA | |
| SCHEMBL12323597 | 0.70 | GAA (0.53) | MDM4TP53KMT2ATHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994362-A | ADMINISTERING FINASTERIDE AND CASODEX | MERCK & CO., INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0514056-A2 | Use of estrogens or antiandrogens for reversal of male sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016233-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC CANCER CONTAINING A 5 ALPHA REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |