SCHEMBL8409657

SCHEMBL8409657

Brc1ccc(OCc2ccccc2)c(/C=C/c2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 6/20 0.57
PTPN1 P18031 1/20 0.54
LMNA P02545 2/20 0.53
USP2 O75604 1/20 0.53
PTP4A3 O75365 1/20 0.52
MAPT P10636 3/20 0.48
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2D6 P10635 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
RAB9A P51151 3/20 0.48
ALDH1A1 P00352 2/20 0.48
SLC6A4 P31645 1/20 0.48
NPC1 O15118 1/20 0.48
RECQL P46063 1/20 0.48
LCK P06239 1/20 0.48
USP28 Q96RU2 1/20 0.47
USP25 Q9UHP3 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8409659 1.00 CCR5 (0.57) CCR5PTPN1LMNAUSP2PTP4A3
SCHEMBL12018748 0.83 CDK4 (0.71) CCR5PTPN1LMNAUSP2PTP4A3
SCHEMBL28324606 0.82 PTGER1 (0.56) LMNAMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL29690396 0.82 PTGDR2 (0.61) CCR5PTPN1LMNAUSP2PTP4A3
SCHEMBL82269 0.82 PTGDR2 (0.61) CCR5PTPN1LMNAUSP2PTP4A3
SCHEMBL2167875 0.82 PTGER4 (0.67) CCR5PTPN1LMNAUSP2PTP4A3
SCHEMBL28740836 0.82 CCR5 (0.57) CCR5PTPN1LMNAUSP2PTP4A3
SCHEMBL2167870 0.82 PTGER4 (0.67) CCR5PTPN1LMNAUSP2PTP4A3
SCHEMBL8708881 0.81 CCNB2 (0.68) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8708880 0.81 CCNB2 (0.68) MAPTCYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0778821-B1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LTD (GB) 1999-10-20 EP disclosed
US-5965741-A ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES ZENECA LIMITED (GB) 1999-10-12 US disclosed
EP-0778821-A1 ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF ZENECA LIMITED (GB) 1997-06-18 EP disclosed