Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 16/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.53 |
| ▸ | RELA | Q04206 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8406806 | 0.89 | MRGPRX4 (0.47) | MRGPRX4SMN1; SMN2GLRA1RAB9AHPGD | |
| SCHEMBL8409882 | 0.84 | MRGPRX4 (0.55) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL8796658 | 0.81 | RXRA (0.47) | MRGPRX4GLRA1MEN1HPGDKMT2A | |
| SCHEMBL22480760 | 0.78 | MRGPRX4 (0.73) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL8406801 | 0.75 | HPGD (0.50) | MRGPRX4GLRA1HPGD | |
| SCHEMBL8798903 | 0.74 | RXRA (0.49) | SMN1; SMN2RAB9AMEN1NPC1HPGD | |
| SCHEMBL8408542 | 0.74 | MRGPRX4 (0.45) | MRGPRX4TP53NFKB1NFKB2RELA | |
| SCHEMBL8409959 | 0.74 | PTGER4 (0.53) | SMN1; SMN2GLRA1MEN1HPGDKMT2A | |
| SCHEMBL8409037 | 0.73 | RXRA (0.53) | SMN1; SMN2RAB9AMEN1NPC1HPGD | |
| SCHEMBL16860678 | 0.73 | GLRA1 (0.79) | MRGPRX4TP53NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0778821-B1 | ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF | ZENECA LTD (GB) | 1999-10-20 | — | — | EP | disclosed |
| US-5965741-A | ANTIINFLAMMATORY, ANTIPYRETIC AND ANTIDIARRHOEAL PROPERTIES | ZENECA LIMITED (GB) | 1999-10-12 | — | — | US | disclosed |