SCHEMBL8410187

SCHEMBL8410187

O=C(O)CCC(O)c1ccc(Cl)nc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.44
NAPRT Q6XQN6 1/20 0.43
AKR1C3 P42330 1/20 0.39
AKR1C2 P52895 1/20 0.39
ADRB1 P08588 2/20 0.39
ADRB3 P13945 2/20 0.39
CYP3A4 P08684 3/20 0.38
CYP2D6 P10635 3/20 0.38
SLC6A2 P23975 3/20 0.38
SLC6A4 P31645 3/20 0.38
SLC6A3 Q01959 3/20 0.38
GLP1R P43220 1/20 0.37
GCGR P47871 1/20 0.37
LMNA P02545 1/20 0.36
ALDH1A1 P00352 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KCNH2 Q12809 1/20 0.36
USP5 P45974 1/20 0.36
KCNQ3 O43525 1/20 0.36
KCNQ2 O43526 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8294048 0.86 CYP3A4 (0.40) FFAR1NAPRTAKR1C3AKR1C2ADRB1
SCHEMBL1983382 0.84 CYP3A4 (0.44) NAPRTADRB1ADRB3CYP3A4CYP2D6
SCHEMBL7101478 0.83 NAPRT (0.46) FFAR1NAPRTAKR1C3AKR1C2ADRB1
SCHEMBL11900194 0.78 CYP3A4 (0.41) NAPRTAKR1C3AKR1C2CYP3A4CYP2D6
SCHEMBL12373162 0.78 AOC3 (0.42) NAPRTCYP3A4CYP2D6SLC6A2SLC6A4
SCHEMBL7115734 0.78 GABBR2 (0.47) CYP3A4CYP2D6LMNAALDH1A1USP5
SCHEMBL6426357 0.75 CYP3A4 (0.43) NAPRTADRB1ADRB3CYP3A4CYP2D6
SCHEMBL6334139 0.75 CYP3A4 (0.43) NAPRTADRB1ADRB3CYP3A4CYP2D6
SCHEMBL6541805 0.75 CYP3A4 (0.43) NAPRTADRB1ADRB3CYP3A4CYP2D6
SCHEMBL2269524 0.75 CYP3A4 (0.39) CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5994540-A HYDROXY- AND CHLORO-PYRIDYLPYRIDAZINONE DERIVATIVES LONZA, LTD. (CH) 1999-11-30 US disclosed
US-5760236-A CHEMICAL INTERMEDIATES FOR PHARMACEUTICALS LONZA, LTD. (CH) 1998-06-02 US disclosed