Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 5/20 | 0.52 |
| ▸ | AXL | P30530 | 4/20 | 0.50 |
| ▸ | MERTK | Q12866 | 3/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58475 | 0.92 | ACVRL1 (0.50) | ACVRL1AXLMERTKERN1RIPK1 | |
| SCHEMBL59280 | 0.90 | ACVRL1 (0.63) | ACVRL1AXLMERTKRIPK1ALDH1A1 | |
| SCHEMBL59409 | 0.88 | ACVRL1 (0.55) | ACVRL1MERTKRIPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL58577 | 0.88 | ERN1 (0.55) | ACVRL1AXLMERTKERN1RIPK1 | |
| SCHEMBL59525 | 0.86 | ACVRL1 (0.53) | ACVRL1AXLMERTKERN1RIPK1 | |
| SCHEMBL878928 | 0.83 | ACVRL1 (0.51) | ACVRL1AXLMERTKERN1KDR | |
| SCHEMBL27747126 | 0.83 | ACVRL1 (0.49) | ACVRL1MERTKERN1KDRKIT | |
| Hydrochloric Acid SCHEMBL27768114 | 0.82 | ACVRL1 (0.63) | ACVRL1AXLMERTKRIPK1KDR | |
| SCHEMBL64952 | 0.82 | ACVRL1 (0.51) | ACVRL1AXLMERTKERN1TYRO3 | |
| SCHEMBL59668 | 0.82 | FLT3 (0.58) | ACVRL1AXLERN1RIPK1TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143393-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100063038-A1 | Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis | BAYER HEALTHCARE LLC | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063038-A1 | Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis | CDK4, CDKL4, MKI67 | ACVRL1 963/4885AXL 2194/4885MERTK 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.