Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.57 |
| ▸ | HTR1B | P28222 | 7/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8883581 | 0.85 | HTR1D (0.56) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL8647276 | 0.79 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL8814138 | 0.79 | HTR1D (0.57) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL13112624 | 0.78 | HTR1A (0.77) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL7479049 | 0.77 | HTR1D (0.69) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL27371806 | 0.77 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL28893758 | 0.77 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL7479054 | 0.76 | HTR1D (0.61) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL4344147 | 0.75 | HTR1D (0.73) | HTR1DHTR1BHTR1AHTR2CADRA2C | |
| SCHEMBL24026446 | 0.75 | HTR1A (0.72) | HTR1DHTR1BHTR1AHTR2CADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889008-A | Substituted 1-indolylpropyl-4-phenethylpiperazadine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1999-03-30 | — | — | US | disclosed |
| US-5854268-A | Azetidine, pyrrolidine and piperidine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-29 | — | — | US | disclosed |