Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Tetrahydrothiophene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrothiophene SCHEMBL9401846 | 0.94 | NOS1 (0.32) | — | |
| Tetrahydrothiophene SCHEMBL2434343 | 0.94 | — | — | |
| Tetrahydrothiophene SCHEMBL9127 | 0.94 | — | — | |
| SCHEMBL11104939 | 0.94 | NOS1 (0.32) | — | |
| Tetrahydrothiophene SCHEMBL599924 | 0.94 | NOS1 (0.32) | — | |
| SCHEMBL12528494 | 0.94 | NOS1 (0.32) | — | |
| Bromide SCHEMBL29766913 | 0.91 | — | — | |
| SCHEMBL619051 | 0.89 | NOS1 (0.30) | — | |
| SCHEMBL3066992 | 0.89 | NOS1 (0.30) | — | |
| SCHEMBL22117137 | 0.89 | NOS1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928305-A1 | HIGH EFFICIENCY LUMINESCENT COPOLYMERS | Cambridge Display Technology Limited (GB) | 1999-07-14 | — | — | EP | disclosed |
| WO-1998032783-A1 | RHEOLOGY MODIFICATION OF PRECURSOR SOLUTIONS | CAMBRIDGE DISPLAY TECHNOLOGY LTD. (GB) | 1998-07-30 | — | — | WO | disclosed |
| WO-1998013408-A1 | HIGH EFFICIENCY LUMINESCENT COPOLYMERS | CAMBRIDGE DISPLAY TECHNOLOGY LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |