Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412080 | 1.00 | SERPINE1 (0.49) | SERPINE1KMT2AMEN1POLBUSP2 | |
| SCHEMBL8639908 | 0.85 | SERPINE1 (0.68) | SERPINE1MAPTDYRK1APIM1DYRK1B | |
| SCHEMBL1166080 | 0.85 | SERPINE1 (0.68) | SERPINE1MAPTDYRK1APIM1DYRK1B | |
| SCHEMBL1166081 | 0.85 | SERPINE1 (0.68) | SERPINE1MAPTDYRK1APIM1DYRK1B | |
| SCHEMBL8639912 | 0.85 | SERPINE1 (0.68) | SERPINE1MAPTDYRK1APIM1DYRK1B | |
| SCHEMBL9186308 | 0.84 | SERPINE1 (0.52) | SERPINE1NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL9186316 | 0.84 | SERPINE1 (0.52) | SERPINE1NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8426197 | 0.84 | SERPINE1 (0.68) | SERPINE1KMT2AMEN1POLBUSP2 | |
| SCHEMBL8426194 | 0.84 | SERPINE1 (0.68) | SERPINE1KMT2AMEN1POLBUSP2 | |
| Dimethylamine SCHEMBL9435678 | 0.80 | SERPINE1 (0.55) | SERPINE1POLBALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995021831-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| WO-1995021830-A1 | PHARMACEUTICAL PIPERAZIN COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | claimed |
| US-5861400-A | TREATING RESISTANCE TO AN ANTHRACYLCINE ANTIBIOTIC WITH ADIKETOPIPERAZINE COMPOUND | XENOVA LIMITED (GB) | 1999-01-19 | — | — | US | disclosed |
| WO-1995021831-A1 | PHARMACEUTICAL PIPERAZINE COMPOUNDS | XENOVA LIMITED (GB) | 1995-08-17 | — | — | WO | disclosed |