Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 3/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9186308 | 1.00 | SERPINE1 (0.52) | SERPINE1RETALOX5TDP1MAPK1 | |
| SCHEMBL8639912 | 0.89 | SERPINE1 (0.68) | SERPINE1ALOX5DYRK1APIM1CSNK2A2 | |
| SCHEMBL8639908 | 0.89 | SERPINE1 (0.68) | SERPINE1ALOX5DYRK1APIM1CSNK2A2 | |
| SCHEMBL1166081 | 0.89 | SERPINE1 (0.68) | SERPINE1ALOX5DYRK1APIM1CSNK2A2 | |
| SCHEMBL1166080 | 0.89 | SERPINE1 (0.68) | SERPINE1ALOX5DYRK1APIM1CSNK2A2 | |
| SCHEMBL9435397 | 0.86 | SERPINE1 (0.53) | SERPINE1NPC1RAB9A | |
| SCHEMBL9187618 | 0.86 | SERPINE1 (0.53) | SERPINE1NPC1RAB9A | |
| SCHEMBL8412080 | 0.84 | SERPINE1 (0.49) | SERPINE1TDP1ALDH1A1PABPC1APOBEC3A | |
| SCHEMBL8412083 | 0.84 | SERPINE1 (0.49) | SERPINE1TDP1ALDH1A1PABPC1APOBEC3A | |
| SCHEMBL9435344 | 0.82 | SERPINE1 (0.46) | SERPINE1RETMAPK1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672036-A1 | PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES | XENOVA LIMITED (GB) | 1995-09-20 | — | — | EP | claimed |
| WO-1994004513-A1 | PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES | XENOVA LIMITED (GB) | 1994-03-03 | — | — | WO | claimed |
| WO-1994004513-A1 | PHARMACEUTICALLY ACTIVE DIKETOPIPERAZINES | XENOVA LIMITED (GB) | 1994-03-03 | — | — | WO | disclosed |