SCHEMBL841285

SCHEMBL841285

CCC(Cl)(c1ccc(CCl)cc1)[Si](C)(C)Cl

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.30
ESR2 Q92731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL840962 0.80
SCHEMBL4590253 0.72 ESR1 (0.37) ESR1ESR2
SCHEMBL840934 0.71 CA1 (0.32) ESR1ESR2
SCHEMBL6299448 0.70 NPC1 (0.46) ESR1ESR2
SCHEMBL5987914 0.68 CA1 (0.38) ESR1ESR2
SCHEMBL8846793 0.68 TSHR (0.46)
SCHEMBL841043 0.67 CA1 (0.32) ESR1ESR2
SCHEMBL839887 0.67
SCHEMBL841793 0.67
SCHEMBL1204683 0.66 TSHR (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2310446-B1 ACTIVATED HALO-CONTAINING ARALKYLSILANE MOMENTIVE PERFORMANCE MAT INC (US) 2015-12-23 EP claimed
US-8143336-B2 Activated halo-containing aralkylsilane composition, process of preparing same and rubber compositions made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2012-03-27 US claimed
US-20100036018-A1 ACTIVATED HALO-CONTAINING ARALKYLSILANE COMPOSITION, PROCESS OF PREPARING SAME AND RUBBER COMPOSITIONS MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. 2010-02-11 US claimed
EP-2310446-B1 ACTIVATED HALO-CONTAINING ARALKYLSILANE MOMENTIVE PERFORMANCE MAT INC (US) 2015-12-23 EP disclosed
US-8143336-B2 Activated halo-containing aralkylsilane composition, process of preparing same and rubber compositions made therefrom MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2012-03-27 US disclosed
EP-2310446-A1 ACTIVATED HALO-CONTAINING ARALKYLSILANE Momentive Performance Materials Inc. (US) 2011-04-20 EP disclosed
WO-2010017370-A1 ACTIVATED HALO-CONTAINING ARALKYLSILANE MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2010-02-11 WO disclosed
US-20100036018-A1 ACTIVATED HALO-CONTAINING ARALKYLSILANE COMPOSITION, PROCESS OF PREPARING SAME AND RUBBER COMPOSITIONS MADE THEREFROM MOMENTIVE PERFORMANCE MATERIALS INC. 2010-02-11 US disclosed