Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 20/20 | 0.55 |
| ▸ | HTR1B | P28222 | 19/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR1F | P30939 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413947 | 0.88 | HTR1D (0.64) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8664623 | 0.86 | HTR1D (0.64) | HTR1DHTR1B | |
| SCHEMBL8413676 | 0.86 | HTR1D (0.55) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8661508 | 0.84 | HTR1D (0.68) | HTR1DHTR1B | |
| SCHEMBL8411688 | 0.84 | HTR1D (0.63) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8411444 | 0.83 | HTR1D (0.62) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8410890 | 0.83 | HTR1D (0.62) | HTR1DHTR1BHTR2AHTR2CHTR1F | |
| SCHEMBL8661968 | 0.83 | HTR1D (0.60) | HTR1DHTR1B | |
| SCHEMBL8699651 | 0.82 | HTR1D (0.64) | HTR1DHTR1B | |
| SCHEMBL8414669 | 0.81 | HTR1D (0.63) | HTR1DHTR1BHTR2AHTR2CHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889008-A | Substituted 1-indolylpropyl-4-phenethylpiperazadine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1999-03-30 | — | — | US | claimed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | claimed |
| US-5889008-A | Substituted 1-indolylpropyl-4-phenethylpiperazadine derivatives | MERCK SHARP & DOHME, LTD. (GB) | 1999-03-30 | — | — | US | disclosed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |