Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | EP300 | Q09472 | 1/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.50 |
| ▸ | ME2 | P23368 | 1/20 | 0.50 |
| ▸ | ME1 | P48163 | 1/20 | 0.50 |
| ▸ | ME3 | Q16798 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8412335 | 0.88 | NPC1 (0.59) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL8413137 | 0.84 | NPC1 (0.67) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL7131839 | 0.79 | NPC1 (0.86) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL25432319 | 0.76 | NPC1 (0.93) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL3700679 | 0.76 | NPC1 (1.00) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL6285963 | 0.75 | NPC1 (0.96) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL17087869 | 0.75 | NPC1 (0.96) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL8414684 | 0.73 | NPC1 (0.65) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL8411392 | 0.73 | NPC1 (0.65) | NPC1TDP1FKBP1APOLBL3MBTL1 | |
| SCHEMBL3796874 | 0.73 | NPC1 (0.75) | NPC1TDP1FKBP1APOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952322-A | AMIDE-SUBSTITUTED BENZIMIDAZOLE, INDOLE DERIVATIVES | PFIZER INC. (US) | 1999-09-14 | — | — | US | claimed |
| US-5952322-A | AMIDE-SUBSTITUTED BENZIMIDAZOLE, INDOLE DERIVATIVES | PFIZER INC. (US) | 1999-09-14 | — | — | US | disclosed |