Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.96 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.96 |
| ▸ | NAAA | Q02083 | 1/20 | 0.79 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | STAT1 | P42224 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | ME2 | P23368 | 1/20 | 0.61 |
| ▸ | ME1 | P48163 | 1/20 | 0.61 |
| ▸ | ME3 | Q16798 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17087869 | 1.00 | NPC1 (0.96) | NPC1TDP1NAAAFKBP1APOLB | |
| SCHEMBL3700679 | 0.98 | NPC1 (1.00) | NPC1TDP1NAAAFKBP1APOLB | |
| SCHEMBL25432319 | 0.95 | NPC1 (0.93) | NPC1TDP1NAAAFKBP1APOLB | |
| SCHEMBL7131839 | 0.91 | NPC1 (0.86) | NPC1TDP1NAAAFKBP1APOLB | |
| SCHEMBL10371234 | 0.90 | NPC1 (0.78) | NPC1TDP1NAAAKMT2AMEN1 | |
| SCHEMBL16333764 | 0.88 | NAAA (1.00) | NPC1TDP1NAAAFKBP1APOLB | |
| SCHEMBL7376148 | 0.88 | NPC1 (0.76) | NPC1TDP1NAAAKMT2AMEN1 | |
| SCHEMBL8599293 | 0.88 | NPC1 (0.81) | NPC1TDP1NAAAKMT2AMEN1 | |
| SCHEMBL3796874 | 0.84 | NPC1 (0.75) | NPC1TDP1NAAAFKBP1APOLB | |
| SCHEMBL4698272 | 0.83 | NPC1 (0.73) | NPC1TDP1NAAAFKBP1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2023-10-17 | — | — | US | claimed |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | NOVARTIS AG (CH) | 2023-04-06 | — | — | US | claimed |
| CN-107108468-A | Inhibitors of lysine porphyromonas gingivalis protease | 库特克希米公司 | 2017-08-29 | — | — | CN | claimed |
| US-20240208923-A1 | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION | JNANA THERAPEUTICS INC. | 2024-06-27 | — | — | US | disclosed |
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2023-10-17 | — | — | US | disclosed |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | NOVARTIS AG (CH) | 2023-04-06 | — | — | US | disclosed |
| US-20220111367-A1 | HYDROGENATION CATALYST FOR USE IN HYDROGENATING AMIDE COMPOUND AND METHOD FOR PRODUCING AMINE COMPOUND USING SAME | OSAKA UNIVERSITY (JP) | 2022-04-14 | — | — | US | disclosed |
| CN-112299938-B | Method for preparing amine compound by reducing amide compound | 中国科学院兰州化学物理研究所 | 2021-12-28 | — | — | CN | disclosed |
| CN-112299938-A | Method for preparing amine compound by reducing amide compound | 中国科学院兰州化学物理研究所 | 2021-02-02 | — | — | CN | disclosed |
| CN-108602787-A | The inhibitor of arginine porphyromonas mycoproteinase | 库特克希米公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-107108468-A | Inhibitors of lysine porphyromonas gingivalis protease | 库特克希米公司 | 2017-08-29 | — | — | CN | disclosed |
| US-8557798-B2 | Macrocyclic heterocyclic aspartyl protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-10-15 | — | — | US | disclosed |
| EP-1636213-B1 | 3-ARYLOXY AND 3-HETEROARYLOXY SUBSTITUTED BENZO(B) THIOPHENES AS THERAPEUTIC AGENTS WITH PI3K ACTIVITY | WARNER LAMBERT CO (US) | 2007-06-13 | — | — | EP | disclosed |
| US-6921762-B2 | Substituted indolizine-like compounds and methods of use | AMGEN INC. (US) | 2005-07-26 | — | — | US | disclosed |
| CN-1019973-C | Piperidine derivative and pharmaceutical composition containing the same | EISAI CO LTD (JP) | 1993-03-03 | — | — | CN | disclosed |
| CN-87100928-A | Piperidine derivatives and pharmaceutical compositions thereof | — | 1987-09-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | HBZ, ZFX, WIZ | NPC1 4529/4885TDP1 2527/4885NAAA 4870/4885 |
| US-20240208923-A1 | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION | SLC18A2, SLC6A19, SLC1A1 | NPC1 116/4885TDP1 1116/4885NAAA 2591/4885 |
| US-20220111367-A1 | HYDROGENATION CATALYST FOR USE IN HYDROGENATING AMIDE COMPOUND AND METHOD FOR PRODUCING AMINE COMPOUND USING SAME | SUV39H2, SUV39H1, HRH3 | NPC1 4484/4885TDP1 3043/4885NAAA 15/4885 |
| US-20230108325-A1 | Pyrazolopyridine Derivatives and Uses thereof | HBZ, ZFX, WIZ | NPC1 4529/4885TDP1 2527/4885NAAA 4870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.