Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 8/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.39 |
| ▸ | RBP1 | P09455 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574945 | 0.92 | PTGIR (0.61) | PTGIRTBXAS1POLBKDM4CPKM | |
| SCHEMBL8413677 | 0.88 | PTGIR (0.46) | PTGIRTBXAS1POLBSIGMAR1NPSR1 | |
| SCHEMBL8808532 | 0.87 | PTGIR (0.46) | PTGIRTBXAS1POLBSIGMAR1NPSR1 | |
| SCHEMBL8813595 | 0.85 | PTGIR (0.45) | PTGIRTBXAS1POLBSIGMAR1NPSR1 | |
| SCHEMBL8410932 | 0.77 | PTGIR (0.61) | PTGIRTBXAS1KDM4C | |
| SCHEMBL8411209 | 0.76 | PTGIR (0.56) | PTGIRTBXAS1SIGMAR1 | |
| SCHEMBL8577075 | 0.76 | PTGIR (0.64) | PTGIRTBXAS1SIGMAR1KDM4C | |
| SCHEMBL8413684 | 0.75 | PTGIR (0.57) | PTGIRTBXAS1SIGMAR1 | |
| SCHEMBL8414245 | 0.75 | PTGIR (0.57) | PTGIRSIGMAR1HTR1AADRA1DADRA1A | |
| SCHEMBL8414212 | 0.74 | PTGIR (0.52) | PTGIRTBXAS1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962439-A | CARDIOVASCULAR DISORDER | ONO PHARMACEUTICAL CO., LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5849919-A | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |