Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOX1 | Q06278 | 1/20 | 0.53 |
| ▸ | RAD52 | P43351 | 5/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415046 | 0.88 | AOX1 (0.53) | AOX1RAD52MEN1KMT2AHDAC1 | |
| SCHEMBL7568211 | 0.87 | AOX1 (0.53) | AOX1RAD52MEN1KMT2AHDAC1 | |
| SCHEMBL7565650 | 0.87 | AOX1 (0.53) | AOX1RAD52HDAC1HDAC6SMARCA2 | |
| SCHEMBL7571848 | 0.85 | AOX1 (0.52) | AOX1RAD52SMARCA2TP53UHRF1 | |
| SCHEMBL7570996 | 0.85 | AOX1 (0.52) | AOX1RAD52MEN1KMT2AHDAC1 | |
| SCHEMBL7564414 | 0.84 | AOX1 (0.45) | AOX1RAD52PARP1MEN1KMT2A | |
| SCHEMBL7026713 | 0.83 | AOX1 (0.76) | AOX1RAD52PARP1HDAC1HDAC6 | |
| SCHEMBL7569139 | 0.83 | AOX1 (0.45) | AOX1RAD52PARP1MEN1KMT2A | |
| SCHEMBL8415065 | 0.81 | AOX1 (0.47) | AOX1RAD52MEN1KMT2AHDAC1 | |
| SCHEMBL7567999 | 0.81 | AOX1 (0.47) | AOX1RAD52MEN1KMT2ASMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934278-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017650-A1 | BIS(ACRIDINECARBOXAMIDE) AND BIS(PHENAZINECARBOXAMIDE) AS ANTITUMOUR AGENTS | XENOVA LIMITED (GB) | 1998-04-30 | — | — | WO | disclosed |