Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isosorbide Mononitrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | BCHE | P06276 | 6/20 | 0.56 |
| ▸ | GSR | P00390 | 7/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosorbide Mononitrate SCHEMBL8893344 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL616518 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL8893635 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL12787633 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL5482432 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL23906861 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL26782 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL8894719 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL22067709 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 | |
| Isosorbide Mononitrate SCHEMBL12238510 | 0.93 | MAPT (1.00) | MAPTALDH1A1BCHEGSRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936901-A1 | PHARMACEUTICAL COMPOSITION FOR RAPID SUSPENSION IN AQUEOUS MEDIA | EURAND INTERNATIONAL S.P.A. (IT) | 1999-08-25 | — | — | EP | claimed |
| WO-1998017250-A1 | PHARMACEUTICAL COMPOSITION FOR RAPID SUSPENSION IN AQUEOUS MEDIA | EURAND INTERNATIONAL S.P.A. (IT) | 1998-04-30 | — | — | WO | claimed |
| EP-0936901-A1 | PHARMACEUTICAL COMPOSITION FOR RAPID SUSPENSION IN AQUEOUS MEDIA | EURAND INTERNATIONAL S.P.A. (IT) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017250-A1 | PHARMACEUTICAL COMPOSITION FOR RAPID SUSPENSION IN AQUEOUS MEDIA | EURAND INTERNATIONAL S.P.A. (IT) | 1998-04-30 | — | — | WO | disclosed |