Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 8/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL343793 | 0.77 | KMT2A (0.50) | MAPTKMT2AKCNN4CES1DRD4 | |
| SCHEMBL8413139 | 0.73 | POLB (0.44) | MAPTKMT2ACYP2D6CYP2C19CHRM2 | |
| SCHEMBL1666946 | 0.66 | CYP1A2 (0.53) | MAPTKMT2AKCNN4KIF11CYP1A2 | |
| SCHEMBL13357533 | 0.66 | KMT2A (0.43) | KMT2ACYP1A2CYP2D6AOC3HIF1A | |
| SCHEMBL8879105 | 0.66 | KMT2A (0.43) | KMT2ACYP1A2CYP2D6AOC3HIF1A | |
| SCHEMBL18493201 | 0.66 | MAPT (0.53) | MAPTKMT2AKCNN4KIF11CYP1A2 | |
| SCHEMBL28393924 | 0.65 | CYP1A2 (0.47) | MAPTKMT2AKCNN4KIF11CYP1A2 | |
| SCHEMBL60359 | 0.65 | CYP1A2 (0.52) | MAPTKMT2AKCNN4KIF11CYP1A2 | |
| SCHEMBL25007307 | 0.65 | PTPN5 (0.48) | KIF11AOC3 | |
| SCHEMBL30222787 | 0.65 | PTPN5 (0.48) | KIF11AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952322-A | AMIDE-SUBSTITUTED BENZIMIDAZOLE, INDOLE DERIVATIVES | PFIZER INC. (US) | 1999-09-14 | — | — | US | disclosed |