SCHEMBL8414924

SCHEMBL8414924

C#CC(C)(C)NC(=O)c1cc(C)cc(C)c1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.48
PKM P14618 1/20 0.48
RAB9A P51151 1/20 0.48
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
TPMT P51580 1/20 0.41
ANO1 Q5XXA6 2/20 0.39
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
TAS1R2 Q8TE23 1/20 0.37
GAA P10253 1/20 0.37
ABCB1 P08183 1/20 0.37
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11884426 0.81 NPC1 (0.45) NPC1PKMRAB9AHTTL3MBTL1
Pronamide SCHEMBL55124 0.81 RAB9A (0.47) NPC1PKMRAB9AHTTL3MBTL1
SCHEMBL27812959 0.81 NPC1 (0.54) NPC1PKMRAB9AHTTL3MBTL1
Pronamide SCHEMBL2045136 0.81 RAB9A (0.47) NPC1PKMRAB9AHTTL3MBTL1
Pronamide SCHEMBL28474286 0.79 RAB9A (0.46) NPC1PKMRAB9AHTTL3MBTL1
Pronamide SCHEMBL28338727 0.79 RAB9A (0.46) NPC1PKMRAB9AHTTL3MBTL1
SCHEMBL4817141 0.79 TPMT (0.48) MEN1KMT2ATPMTANO1TAS1R3
Pronamide SCHEMBL28908557 0.78 RAB9A (0.45) NPC1PKMRAB9AHTTL3MBTL1
SCHEMBL4941829 0.76 NPC1 (0.64) NPC1PKMRAB9AMEN1KMT2A
Pronamide SCHEMBL28937485 0.76 ANO1 (0.43) NPC1PKMRAB9AHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5977368-A Process to chloroketones using oxazolines ROHM AND HAAS COMPANY (US) 1999-11-02 US disclosed
US-5959114-A CYCLIZING AN ALKYNYLAMIDO USING AN ACID ROHM AND HAAS COMPANY (US) 1999-09-28 US disclosed
US-5942621-A CYCLIZING AN ALKYNYL AMIDE USING A MILD AQUEOUS BASE IN THE PRESENCE OF AN ORGANIC SOLVENT AND PHASE TRANSFER AGENT TO YIELD A 5-METHYLENEOXAZOLINE CHEMICAL INTERMEDIATE TO COST EFFICIENT ALPHA-CHLOROKETONE FUNGICIDE PRODUCTION ROHM AND HAAS COMPANY (US) 1999-08-24 US disclosed
US-5936096-A TRICHLOROISOCYANURIC ACID USED AS SELECTIVE CHLORINATION REAGENT IN THE CHLORINATION OF A 5-METHYLENEOXAZOLINE TO A CHLORINATED INTERMEDIATE WHICH CAN BY HYROLYZED WITH AN AQUEOUS ACID TO PRODUCE MONOCHLOROKETONE FUNGICIDES ROHM AND HAAS COMPANY (US) 1999-08-10 US disclosed
US-5932738-A TRICHLOROISOCYANURIC ACID USED AS SELECTIVE CHLORINATION REAGENT IN THE CHLORINATION OF A 5-METHYLENEOXAZOLINE TO A CHLORINATED INTERMEDIATE WHICH CAN BY HYROLYZED WITH AN AQUEOUS ACID TO PRODUCE MONOCHLOROKETONE FUNGICIDES ROHM AND HAAS COMPANY (US) 1999-08-03 US disclosed
US-5925763-A MULTISTAGE PROCESS WITH CYCLIZATION OF AN ALKYNYL AMIDE TO FORM METHYLENEOXAZOLINE, CHLORINATION USING TRICHLOROISOCYANURIC ACID TO PRODUCE DICHLOROXAZOLINE INTERMEDIATES AND HYDROLYSIS ROHM AND HAAS COMPANY (US) 1999-07-20 US disclosed
US-5859254-A CYCLIZING ALKYNYLAMIDE USING AQUEOUS BASE IN PRESENCE OF ORGANIC SOLVENT AND PHASE TRANSFER AGENT, CHLORINATING PRODUCT IN SOLVENT WITH TRICHLOROISOCYANURIC ACID, HYDROLYZING CHLORINATED OXAZOLINE WITH AQUEOUS ACID ROHM AND HAAS COMPANY (US) 1999-01-12 US disclosed
EP-0872474-A2 Process for the preparation of chloroketones using oxazolines ROHM AND HAAS COMPANY (US) 1998-10-21 EP disclosed