Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 10/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 5/20 | 0.37 |
| ▸ | CASP6 | P55212 | 3/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8410793 | 0.87 | CASP1 (0.55) | CASP1L3MBTL1CASP3CASP6CASP8 | |
| SCHEMBL7419593 | 0.83 | CASP1 (0.61) | CASP1L3MBTL1CASP3CASP6CASP8 | |
| SCHEMBL8413808 | 0.82 | CASP1 (0.46) | CASP1L3MBTL1CASP3CASP6CASP8 | |
| SCHEMBL8414714 | 0.82 | CASP1 (0.52) | CASP1L3MBTL1CASP3CASP6CASP8 | |
| SCHEMBL7414025 | 0.80 | CASP1 (0.59) | CASP1L3MBTL1CASP3CASP6CASP8 | |
| SCHEMBL7461546 | 0.79 | CASP1 (0.65) | CASP1CASP3CASP6CASP8HPGD | |
| SCHEMBL7419608 | 0.78 | CASP1 (0.66) | CASP1CASP3CASP6CASP8CASP7 | |
| SCHEMBL7417899 | 0.78 | CASP1 (0.62) | CASP1L3MBTL1CASP3CASP6CASP8 | |
| SCHEMBL8413558 | 0.77 | HDAC3 (0.33) | — | |
| SCHEMBL7421737 | 0.77 | CASP1 (0.62) | CASP1CASP3CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932598-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-08-04 | — | — | EP | disclosed |
| WO-1998016502-A1 | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1998-04-23 | — | — | WO | disclosed |