Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 4/20 | 0.45 |
| ▸ | CCND1 | P24385 | 4/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649929 | 0.83 | HTR6 (0.61) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL4065276 | 0.83 | HTR6 (0.61) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL29558089 | 0.83 | HTR6 (0.61) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL24596834 | 0.83 | HTR6 (0.61) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL5636978 | 0.83 | HTR6 (0.61) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL6585634 | 0.82 | HTR6 (0.57) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL29576587 | 0.82 | HTR6 (0.57) | HTR6HTTKMT2AMEN1TSHR | |
| Benzene SCHEMBL29208974 | 0.81 | HTR6 (0.65) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL6359369 | 0.79 | HTR6 (0.58) | HTR6HTTKMT2AMEN1TSHR | |
| SCHEMBL10433225 | 0.79 | HTR6 (0.58) | HTR6HTTKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667350-B1 | Water-soluble phosphine-derivatives | HOFFMANN LA ROCHE (CH) | 1999-09-01 | — | — | EP | disclosed |
| US-5536858-A | CATALYSTS FOR HYDROGENATION USING PHOSPHINEARYLSULFONATES | HOFFMANN-LA ROCHE INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0667350-A1 | Water-soluble phosphine-derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-08-16 | — | — | EP | disclosed |