Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 5/20 | 0.38 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.38 |
| ▸ | PPARG | P37231 | 6/20 | 0.38 |
| ▸ | PPARD | Q03181 | 6/20 | 0.38 |
| ▸ | PPARA | Q07869 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TLR2 | O60603 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL10578460 | 0.96 | FFAR3 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Lactic Acid SCHEMBL21464736 | 0.91 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Lactic Acid SCHEMBL183593 | 0.91 | FFAR3 (0.68) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL27473502 | 0.89 | FFAR3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Lactic Acid SCHEMBL29090830 | 0.89 | FFAR3 (0.65) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Lactic Acid SCHEMBL11064545 | 0.89 | TP53 (0.61) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Succinic Acid SCHEMBL27677676 | 0.88 | FFAR3 (0.43) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL19800894 | 0.87 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL28969308 | 0.86 | FFAR3 (0.68) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL188036 | 0.86 | FFAR3 (0.77) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1261561-C | Process for preparing high active powder composite green storage inoculating agent and its carrier adsorption agent | UNIV SOUTHERN YANGTZE (CN) | 2006-06-28 | — | — | CN | disclosed |
| CN-1777671-A | Novel galactooligosaccharide composition and preparation thereof | CLASADO INC (PA) | 2006-05-24 | — | — | CN | disclosed |
| CN-1537814-A | Microorganism metabolism type regulate and control method, in sulphate waste water treatment | 哈尔滨工业大学 | 2004-10-20 | — | — | CN | disclosed |
| CN-1409986-A | Special lactobacillus inoculum for silage and its making method | WANG JIANHUA (CN) | 2003-04-16 | — | — | CN | disclosed |
| US-5952314-A | SOURCE OF INDIGESTIBLE CARBOHYDRATE WHICH IS METABOLIZED TO SHORT CHAIN FATTY ACIDS BY MICROORGANISMS PRESENT IN HUMAN COLON, OIL BLEND | DEMICHELE STEPHEN JOSEPH (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0754001-A1 | NUTRITIONAL PRODUCT FOR TREATMENT OF ULCERATIVE COLITIS AND USE THEREOF | ABBOTT LABORATORIES (US) | 1997-01-22 | — | — | EP | disclosed |
| WO-1995026646-A1 | NUTRITIONAL PRODUCT FOR TREATMENT OF ULCERATIVE COLITIS AND USE THEREOF | ABBOTT LABORATORIES (US) | 1995-10-12 | — | — | WO | disclosed |
| US-5444054-A | Enterally feeding source of digestible carbohydrates which metabolizes to fatty acids, and an oil blend containing fatty acids | ABBOTT LABATORIES (US) | 1995-08-22 | — | — | US | disclosed |