Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415790 | 0.94 | HTR2C (0.67) | HTR2CCYP19A1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8418107 | 0.88 | CYP19A1 (0.56) | HTR2CCYP19A1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9055209 | 0.86 | HTR2C (0.79) | HTR2CCYP19A1ALDH1A1POLBYES1 | |
| Fumaric Acid SCHEMBL8416954 | 0.86 | HTR2C (0.60) | HTR2CCYP19A1ALDH1A1CYP3A4CYP2D6 | |
| Maleic Acid SCHEMBL8416947 | 0.86 | HTR2C (0.60) | HTR2CCYP19A1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9056449 | 0.85 | CYP19A1 (0.55) | HTR2CCYP19A1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL8418190 | 0.81 | CYP19A1 (0.58) | HTR2CCYP19A1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL9054532 | 0.79 | HTR2C (0.49) | HTR2CALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL26391933 | 0.79 | HTR2C (1.00) | HTR2CCYP19A1ALDH1A1POLBKMT2A | |
| SCHEMBL8418131 | 0.75 | CYP19A1 (0.54) | HTR2CCYP19A1ALDH1A1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965582-A | ANTIHISTAMINES | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1999-10-12 | — | — | US | claimed |
| EP-0775131-A2 | INDOL, INDAZOL, PYRIDOPYRROL AND PYRIDOPYRAZOL DERIVATIVES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING EFFECTS | ASTA Medica Aktiengesellschaft (DE) | 1997-05-28 | — | — | EP | claimed |
| WO-1996004266-A2 | INDOL, INDAZOL, PYRIDOPYRROL AND PYRIDOPYRAZOL DERIVATIVES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING EFFECTS | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1996-02-15 | — | — | WO | claimed |