Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 14/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | FLT3 | P36888 | 3/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | AKT2 | P31751 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8415630 | 1.00 | PAK1 (1.00) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| SCHEMBL8808140 | 0.90 | PAK1 (0.82) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| SCHEMBL8585963 | 0.90 | PAK1 (0.82) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| SCHEMBL8428761 | 0.87 | MAPK1 (1.00) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| SCHEMBL6266403 | 0.87 | MAPK1 (1.00) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| SCHEMBL29537607 | 0.87 | MAPK1 (1.00) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| SCHEMBL29355210 | 0.87 | MAPK1 (1.00) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| Hydrochloric Acid SCHEMBL7554275 | 0.87 | PAK1 (0.77) | PAK1MAPK1FLT3CSF1RPDGFRB | |
| SCHEMBL8530470 | 0.84 | PAK1 (0.72) | PAK1MAPK1 | |
| SCHEMBL8585959 | 0.82 | PAK1 (0.70) | PAK1MAPK1FLT3PDPK1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752985-B1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 1999-08-04 | — | — | EP | claimed |
| EP-0752985-B1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 1999-08-04 | — | — | EP | disclosed |
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | disclosed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |