Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 9/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | TERT | O14746 | 3/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | LTK | P29376 | 2/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | CDK7 | P50613 | 2/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | MST1R | Q04912 | 2/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808140 | 1.00 | PAK1 (0.82) | PAK1MAPK1TERTNTRK1FLT3 | |
| SCHEMBL8415627 | 0.90 | PAK1 (1.00) | PAK1MAPK1NTRK1FLT3PDGFRB | |
| SCHEMBL8415630 | 0.90 | PAK1 (1.00) | PAK1MAPK1NTRK1FLT3PDGFRB | |
| SCHEMBL8321792 | 0.88 | PAK1 (0.69) | PAK1MAPK1TERTHPGDS | |
| SCHEMBL29537607 | 0.86 | MAPK1 (1.00) | PAK1MAPK1NTRK1FLT3PDGFRB | |
| SCHEMBL6266403 | 0.86 | MAPK1 (1.00) | PAK1MAPK1NTRK1FLT3PDGFRB | |
| SCHEMBL29355210 | 0.86 | MAPK1 (1.00) | PAK1MAPK1NTRK1FLT3PDGFRB | |
| SCHEMBL8428761 | 0.86 | MAPK1 (1.00) | PAK1MAPK1NTRK1FLT3PDGFRB | |
| Hydrochloric Acid SCHEMBL7554275 | 0.81 | PAK1 (0.77) | PAK1MAPK1FLT3PDGFRBKDR | |
| SCHEMBL8586376 | 0.80 | NTRK1 (0.63) | PAK1MAPK1NTRK1FLT3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | claimed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | claimed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | claimed |
| US-5840745-A | INHIBITING CELL PROLIFERATION, TUMOR GROWTH, METASTASIS, DEVELOPMENT OF ATHEROMATOUS PLAQUE AND RESTENOSIS, CONTROLLING ANGIOGENESIS, TREATING DIABETES, ENHANCING CANCER THERAPY | PHARMACIA S. P. A. (IT) | 1998-11-24 | — | — | US | disclosed |
| EP-0752985-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-01-15 | — | — | EP | disclosed |
| WO-1996022976-A1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1996-08-01 | — | — | WO | disclosed |