Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | PPM1B | O75688 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499484 | 0.81 | LOXL2 (0.48) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL9378795 | 0.78 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL9375934 | 0.78 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL10374052 | 0.78 | CYP4F2 (0.50) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL8418584 | 0.77 | LOXL2 (0.47) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL8418580 | 0.77 | LOXL2 (0.47) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL8418579 | 0.77 | LOXL2 (0.47) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL15981992 | 0.77 | LOXL2 (0.41) | LOXL2CYP4F2CYP4A11TSHRRAB9A | |
| SCHEMBL15298368 | 0.76 | SLC5A2 (0.56) | — | |
| SCHEMBL8418720 | 0.75 | LOXL2 (0.44) | LOXL2CYP4F2CYP4A11TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990326-A | AN ANTIINFLAMMATORY AGENT AS INHIBITORS OF LEUKOTRIENE HYDROLASE | G.D. SEARLE & CO. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0360246-B1 | 3-Oxiranyl benzoic acids and derivatives thereof | SEARLE & CO (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0360246-A1 | 3-Oxiranyl benzoic acids and derivatives thereof | G.D. Searle & Co. (US) | 1990-03-28 | — | — | EP | disclosed |