Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 2/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3356044 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL8418442 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL3356045 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL8418476 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL16106168 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL8420444 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL8420445 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL3356049 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL16106169 | 1.00 | TLR4 (0.35) | TLR4FNTAPGGT1B | |
| SCHEMBL8420604 | 0.86 | L3MBTL1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2189442-B1 | Process and intermediates for the preparation of aliskiren | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-10-01 | — | — | EP | disclosed |
| EP-2189442-A1 | Process and intermediates for the preparation of aliskiren | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2010-05-26 | — | — | EP | disclosed |