SCHEMBL8416116

SCHEMBL8416116

CC[Si](CC)(CC)c1c(Cl)ccc(O)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.46
MAPK1 P28482 1/20 0.46
TSHR P16473 3/20 0.35
AR P10275 2/20 0.32
ESR1 P03372 2/20 0.32
ESR2 Q92731 2/20 0.32
NR1H2 P55055 1/20 0.32
NR1H3 Q13133 1/20 0.32
HSP90AA1 P07900 2/20 0.32
HSP90AB1 P08238 1/20 0.32
KDM4E B2RXH2 1/20 0.32
BRD4 O60885 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
METAP2 P50579 1/20 0.32
METAP1 P53582 1/20 0.32
HSD17B10 Q99714 2/20 0.31
ALDH1A1 P00352 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
RORC P51449 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8415503 0.77 CYP3A4 (0.52) CYP3A4MAPK1TSHRESR1ESR2
SCHEMBL27695109 0.70 CYP3A4 (0.54) CYP3A4MAPK1TSHRARESR1
SCHEMBL28985928 0.67 CYP3A4 (0.50) CYP3A4MAPK1TSHRHSP90AA1HSP90AB1
Methyl Alcohol SCHEMBL28055212 0.66 CYP3A4 (0.89) CYP3A4MAPK1TSHRARESR1
Ethane SCHEMBL28069740 0.66 CYP3A4 (0.89) CYP3A4MAPK1TSHRARESR1
Propane SCHEMBL10791092 0.65 MAPK1 (0.48) CYP3A4MAPK1TSHRARHSP90AA1
SCHEMBL136940 0.65 CYP3A4 (1.00) CYP3A4MAPK1TSHRARESR1
SCHEMBL3246842 0.64 CYP3A4 (0.59) CYP3A4MAPK1TSHRESR1ESR2
SCHEMBL23227095 0.64 CYP3A4 (0.52) CYP3A4MAPK1TSHRARESR1
SCHEMBL31392414 0.64 CYP3A4 (0.75) CYP3A4MAPK1TSHRESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0601642-B1 Photographic silver halide material and process EASTMAN KODAK CO (US) 1999-09-01 EP disclosed
EP-0601642-A1 Photographic silver halide material and process EASTMAN KODAK COMPANY (US) 1994-06-15 EP disclosed
US-5306604-A Dispersibility, low melting points EASTMAN KODAK COMPANY (US) 1994-04-26 US disclosed