Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | ATP1A1 | P05023 | 7/20 | 0.74 |
| ▸ | ATP1B1 | P05026 | 7/20 | 0.74 |
| ▸ | ATP1A3 | P13637 | 7/20 | 0.74 |
| ▸ | ATP1B2 | P14415 | 7/20 | 0.74 |
| ▸ | ATP1A2 | P50993 | 7/20 | 0.74 |
| ▸ | ATP1B3 | P54709 | 7/20 | 0.74 |
| ▸ | FXYD2 | P54710 | 7/20 | 0.74 |
| ▸ | ATP1A4 | Q13733 | 7/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | ATP12A | P54707 | 1/20 | 0.74 |
| ▸ | SLCO4C1 | Q6ZQN7 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gitoxigenin SCHEMBL644087 | 1.00 | TP53 (1.00) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| Gitoxigenin SCHEMBL3302691 | 1.00 | TP53 (1.00) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| Gitoxigenin SCHEMBL13338042 | 1.00 | TP53 (1.00) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| Gitoxigenin SCHEMBL19638184 | 1.00 | TP53 (1.00) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| Gitoxigenin SCHEMBL3302694 | 1.00 | TP53 (1.00) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| SCHEMBL14681100 | 0.88 | TP53 (0.79) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| SCHEMBL4905625 | 0.88 | TP53 (0.84) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| SCHEMBL17864015 | 0.88 | TP53 (0.84) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| SCHEMBL11408235 | 0.87 | TP53 (0.77) | TP53RAB9ACYP2C19ATP1A1ATP1B1 | |
| SCHEMBL21578190 | 0.87 | TP53 (0.77) | TP53RAB9ACYP2C19ATP1A1ATP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0941733-A2 | Methods of inhibiting leaderless protein export using cardiac glycosides and derivatives | The Scripps Research Institute (US) | 1999-09-15 | — | — | EP | disclosed |
| EP-0828497-B1 | METHODS OF INHIBITING LEADERLESS PROTEIN EXPORT USING CARDIAC GLYCOSIDES OR AGLYCONES THEREFROM AND DERIVATIVES | SCRIPPS RESEARCH INST (US) | 1999-09-01 | — | — | EP | disclosed |