SCHEMBL8417364

SCHEMBL8417364

CC(C)(C)c1ccccc1Nc1ccc(-c2ccc(Nc3ccccc3C(C)(C)C)cc2-c2ccccc2)c(-c2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.41
GRIN2D O15399 1/20 0.37
GRIN3B O60391 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2A Q12879 1/20 0.37
GRIN2B Q13224 1/20 0.37
GRIN2C Q14957 1/20 0.37
GRIN3A Q8TCU5 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
ALDH1A1 P00352 1/20 0.37
P2RY1 P47900 5/20 0.36
POLB P06746 1/20 0.36
GAA P10253 1/20 0.36
THRB P10828 1/20 0.36
ALOX12 P18054 1/20 0.36
MAPK14 Q16539 1/20 0.36
APP P05067 1/20 0.36
TAS2R14 Q9NYV8 1/20 0.35
LMNA P02545 1/20 0.34
PTGS1 P23219 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25502785 0.84 GAA (0.42) IDO1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL26157618 0.82 IDO1 (0.39) IDO1ALDH1A1POLBGAATHRB
SCHEMBL28793668 0.82 PTGER4 (0.42) IDO1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL25124835 0.80 IDO1 (0.36) IDO1PTGS1PTGS2KCNK18
SCHEMBL9006076 0.79 MAPK14 (0.44) ALDH1A1GAAMAPK14APPLMNA
SCHEMBL8417367 0.79 IDO1 (0.42) IDO1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8962199 0.77 TDP1 (0.50) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL26157678 0.77 GAA (0.38) IDO1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL30301269 0.76 FABP3 (0.47) ALDH1A1MAPK14APPLMNASIRT2
SCHEMBL25125190 0.76 FABP3 (0.47) ALDH1A1MAPK14APPLMNASIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0597128-B1 ESTER POLYMER, PRODUCTION THEREOF, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE THEREFROM IDEMITSU KOSAN CO (JP) 1999-09-15 EP disclosed
EP-0582722-B1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE FROM POLYCARBONATE POLYMER IDEMITSU KOSAN CO (JP) 1997-11-12 EP disclosed
EP-0411192-B1 Electrophotographic photoreceptor IDEMITSU KOSAN CO (JP) 1995-06-07 EP disclosed
EP-0597128-A1 ESTER POLYMER, PRODUCTION THEREOF, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE THEREFROM IDEMITSU KOSAN COMPANY LIMITED (JP) 1994-05-18 EP disclosed
EP-0582722-A1 POLYCARBONATE POLYMER, PRODUCTION THEREOF, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR MADE THEREFROM IDEMITSU KOSAN COMPANY LIMITED (JP) 1994-02-16 EP disclosed
EP-0411192-A1 Electrophotographic photoreceptor IDEMITSU KOSAN COMPANY LIMITED (JP) 1991-02-06 EP disclosed