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SCHEMBL8417482

SCHEMBL8417482

COC(=O)CCCc1ccc(C(N)CCCC(F)(F)C(F)(F)C(F)(F)F)s1

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.44
▸ RPS6KB2 Q9UBS0 1/20 0.33
▸ APP P05067 2/20 0.33
▸ MLYCD O95822 2/20 0.33
▸ TRPV1 Q8NER1 1/20 0.32
▸ PTPRB P23467 1/20 0.32
▸ PKM P14618 1/20 0.32
▸ TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8421565 0.97 HPGD (0.43) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8421830 0.94 HPGD (0.42) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8419344 0.93 HPGD (0.45) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8419468 0.91 HPGD (0.44) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8418011 0.90 HPGD (0.41) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8419376 0.90 HPGD (0.44) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8417522 0.90 HPGD (0.44) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8419778 0.90 HPGD (0.50) HPGDRPS6KB2APPMLYCDPKM
SCHEMBL8421492 0.90 HPGD (0.46) HPGDRPS6KB2APPMLYCDTRPV1
SCHEMBL8421209 0.88 HPGD (0.43) HPGDRPS6KB2APPMLYCDTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0943606-A1 BENZENESULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME HOKURIKU SEIYAKU CO., LTD. (JP) 1999-09-22 — — EP disclosed