Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8416209 | 0.88 | KCNH2 (0.45) | DRD3LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8866468 | 0.88 | KCNH2 (0.48) | DRD3LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8417837 | 0.88 | KCNH2 (0.45) | DRD3MAPTDRD2ADRA1DADRA1A | |
| Water SCHEMBL7130515 | 0.87 | KCNH2 (0.49) | DRD3LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8865630 | 0.84 | HTR4 (0.52) | DRD3LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8865738 | 0.84 | KCNH2 (0.52) | DRD3LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8866229 | 0.84 | HTR4 (0.64) | DRD3MAPTALDH1A1DRD2ADRA1D | |
| SCHEMBL29904381 | 0.84 | HTR4 (0.52) | DRD3LMNAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8415110 | 0.82 | HTR2A (0.54) | DRD3LMNAMAPTALDH1A1DRD2 | |
| SCHEMBL21652028 | 0.80 | CHRM5 (0.52) | ALDH1A1SMN1; SMN2DRD2CCR3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650475-B1 | 4-AMINO-N-(4-METHYL-4-PIPERIDINYL)-2-METHOXYBENZAMIDES, THEIR PREPARATION AND THEIR USE AS 5-HT2 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 1999-09-01 | — | — | EP | claimed |
| EP-0650475-B1 | 4-AMINO-N-(4-METHYL-4-PIPERIDINYL)-2-METHOXYBENZAMIDES, THEIR PREPARATION AND THEIR USE AS 5-HT2 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 1999-09-01 | — | — | EP | disclosed |