Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8419515 | 0.86 | TSHR (0.47) | TSHRGABRA1GABRB2MLNRCYP3A4 | |
| SCHEMBL8366286 | 0.86 | MEN1 (0.47) | GABRA1GABRB2SLC6A3LTB4R2RORB | |
| SCHEMBL8369232 | 0.85 | MEN1 (0.46) | GABRA1GABRB2SLC6A3LTB4R2RORB | |
| SCHEMBL8417934 | 0.73 | TSHR (0.53) | TSHRGABRA1GABRB2SLC6A3HPGD | |
| SCHEMBL8417383 | 0.72 | MEN1 (0.42) | GABRA1GABRB2SLC6A3RORBCHRM1 | |
| SCHEMBL3629780 | 0.72 | MEN1 (0.66) | TSHRMLNRCYP3A4ALOX5APFEN1 | |
| SCHEMBL14134245 | 0.71 | KEAP1 (0.54) | TSHRGABRA1GABRB2MLNRCYP3A4 | |
| SCHEMBL1515709 | 0.71 | EIF4E (0.58) | SLC6A3ALOX5APFEN1RORBCHRM1 | |
| SCHEMBL9195599 | 0.71 | SLC6A2 (0.58) | TSHRGABRA1GABRB2SLC6A3ALOX5AP | |
| SCHEMBL8368909 | 0.70 | MEN1 (0.41) | GABRA1GABRB2RORBCHRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861392-A | NONPEPTIDE ANTAGONISTS OF NEUROKININ A USEFUL FOR THE TREATMENT OF ASTHMA | ZENECA LIMITED (GB) | 1999-01-19 | — | — | US | disclosed |
| US-5677317-A | Lactam compounds which are useful in the treatment of asthma | ZENECA LIMITED (GB) | 1997-10-14 | — | — | US | disclosed |