SCHEMBL8419346

SCHEMBL8419346

CCCCC[Si@H]1CC[C@H](CC[C@H]2CC[C@H](c3cc(F)c(Cl)c(F)c3)CC2)CC1

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
OPRL1 P41146 3/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
CYP2C9 P11712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8419349 1.00 OPRL1 (0.31) OPRL1MEN1KMT2ACYP2C9
SCHEMBL7759601 0.90 MEN1 (0.32) MEN1KMT2ACYP2C9
SCHEMBL7759606 0.90 MEN1 (0.32) MEN1KMT2ACYP2C9
SCHEMBL8858378 0.90 GRM2 (0.31)
SCHEMBL8858379 0.90 GRM2 (0.31)
SCHEMBL7767664 0.89 OPRL1 (0.32) OPRL1CYP2C9
SCHEMBL7767671 0.89 OPRL1 (0.32) OPRL1CYP2C9
SCHEMBL7767668 0.89 OPRL1 (0.32) OPRL1CYP2C9
SCHEMBL7766289 0.86 MEN1 (0.36) MEN1KMT2ACYP2C9
SCHEMBL7766296 0.86 MEN1 (0.36) MEN1KMT2ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648773-B1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 1999-09-08 EP disclosed
US-5547606-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-08-20 US disclosed
EP-0648773-A1 A silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-04-19 EP disclosed