Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | SGK1 | O00141 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8421107 | 0.91 | PTGS2 (0.47) | PTGS2PTGS1CA9SGK1F10 | |
| SCHEMBL8423417 | 0.90 | PTGS2 (0.39) | PTGS2PTGS1F10ALOX5APFEN1 | |
| SCHEMBL8421300 | 0.90 | PTGS2 (0.39) | PTGS2PTGS1SGK1F10TRPV1 | |
| SCHEMBL8419909 | 0.86 | PTGS2 (0.46) | PTGS2PTGS1CA2CA9 | |
| SCHEMBL8419780 | 0.85 | DHODH (0.41) | PTGS2CA2CA9F10LTB4R | |
| SCHEMBL8419433 | 0.85 | PTGS2 (0.47) | PTGS2PTGS1SGK1F10 | |
| SCHEMBL8419782 | 0.85 | PTGS2 (0.47) | PTGS2PTGS1SGK1F10ALOX5AP | |
| SCHEMBL8423492 | 0.84 | PTGS2 (0.38) | PTGS2PTGS1SGK1F10ALOX5AP | |
| SCHEMBL8423196 | 0.80 | SGK1 (0.42) | PTGS2PTGS1CA9SGK1F10 | |
| SCHEMBL8423260 | 0.80 | SGK1 (0.42) | PTGS2PTGS1CA9SGK1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |