Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 8/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8779469 | 0.90 | TNF (0.42) | TNFALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8421376 | 0.86 | TNF (0.56) | TNFALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8421923 | 0.86 | TNF (0.56) | TNFALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8419507 | 0.86 | KDM4E (0.44) | TNFALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8779410 | 0.84 | TNF (0.49) | TNFALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8779401 | 0.83 | HSD17B10 (0.41) | TNFALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL7856722 | 0.81 | TNF (0.56) | TNFALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL7846184 | 0.79 | PDE4A (0.60) | TNFALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL825934 | 0.78 | TNF (0.48) | TNFKDM4EPDE4APDE4BPDE4C | |
| SCHEMBL8779441 | 0.78 | CYP1A2 (0.39) | ALDH1A1KDM4EHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942902-A2 | NOVEL IMMUNOTHERAPEUTIC IMIDES/AMIDES | CELGENE CORPORATION (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998024763-A2 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AS PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-06-11 | — | — | WO | disclosed |
| EP-0797437-A1 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a) | CELGENE CORPORATION (US) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996020705-A1 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a) | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |