Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420151 | 0.83 | TNF (0.43) | PDE4ALMNAPDE4BPDE4CPDE4D | |
| SCHEMBL7437121 | 0.78 | TNF (0.60) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL8421923 | 0.78 | TNF (0.56) | HSD17B10PDE4ALMNAPDE4BPDE4C | |
| SCHEMBL8421376 | 0.78 | TNF (0.56) | HSD17B10PDE4ALMNAPDE4BPDE4C | |
| SCHEMBL8419507 | 0.78 | KDM4E (0.44) | PDE4ALMNAPDE4BPDE4CPDE4D | |
| SCHEMBL8779410 | 0.76 | TNF (0.49) | HSD17B10PDE4ALMNAPDE4BPDE4C | |
| SCHEMBL8418437 | 0.74 | LMNA (0.42) | HSD17B10LMNAPTAFRPOLBALDH1A1 | |
| SCHEMBL7432875 | 0.74 | KMT2A (0.53) | TNFMEN1KMT2A | |
| SCHEMBL8779469 | 0.74 | TNF (0.42) | PDE4ALMNAPDE4BPDE4CPDE4D | |
| SCHEMBL7856722 | 0.74 | TNF (0.56) | PDE4ALMNAPDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797437-A1 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a) | CELGENE CORPORATION (US) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996020705-A1 | IMMUNOTHERAPEUTIC IMIDES/AMIDES AND THEIR USE FOR REDUCING LEVELS OF TNF$g(a) | CELGENE CORPORATION (US) | 1996-07-11 | — | — | WO | disclosed |