Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.61 |
| ▸ | PRSS1 | P07477 | 14/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404488 | 1.00 | F2 (0.61) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7817428 | 0.92 | F2 (0.52) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7817562 | 0.86 | F2 (0.44) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7818207 | 0.83 | F2 (0.47) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7505080 | 0.83 | F2 (0.61) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7405928 | 0.83 | F2 (0.61) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7817431 | 0.83 | F2 (0.61) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL8418959 | 0.83 | F2 (0.61) | F2PRSS1PRSS2PRSS3MASP2 | |
| SCHEMBL7817408 | 0.83 | F2 (0.43) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7817861 | 0.81 | F2 (0.61) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5866573-A | Pyrazinone thrombin inhibitors | MERCK & CO., INC. (US) | 1999-02-02 | — | — | US | disclosed |