Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 18/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423958 | 0.89 | PTGS2 (0.60) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8420778 | 0.88 | PTGS1 (0.59) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8420789 | 0.87 | PTGS1 (0.58) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8423846 | 0.87 | PTGS1 (0.58) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8423780 | 0.87 | PTGS1 (0.58) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8111966 | 0.86 | PTGS2 (0.70) | PTGS1PTGS2 | |
| SCHEMBL8423926 | 0.86 | PTGS1 (0.57) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8420080 | 0.86 | PTGS2 (0.59) | PTGS1PTGS2 | |
| SCHEMBL8423907 | 0.85 | PTGS1 (0.56) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8423994 | 0.84 | PTGS2 (0.55) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |
| US-5434178-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G.D. SEARLE & CO. (US) | 1995-07-18 | — | — | US | disclosed |