Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423635 | 0.91 | AURKA (0.43) | PTGS2KDM4ELMNAKAT6AHTR6 | |
| SCHEMBL8641239 | 0.89 | KAT6A (0.44) | PTGS2KDM4ELMNAKAT6AHTR6 | |
| SCHEMBL8421776 | 0.88 | KDM1A (0.47) | PTGS2KDM4EKAT6APTGS1MALT1 | |
| SCHEMBL8641119 | 0.87 | AURKA (0.46) | PTGS2KDM4EKAT6APTGS1MALT1 | |
| SCHEMBL8422366 | 0.85 | KDM1A (0.46) | PTGS2HTR6MALT1KDM1AGAA | |
| SCHEMBL8420906 | 0.85 | KDM1A (0.46) | PTGS2HTR6MALT1KDM1AGAA | |
| SCHEMBL8421897 | 0.83 | USP8 (0.44) | PTGS2LMNAHTR6PTGS1MALT1 | |
| SCHEMBL8420731 | 0.83 | KDM1A (0.43) | PTGS2KDM4ELMNAMALT1KDM1A | |
| SCHEMBL8423764 | 0.83 | MAPT (0.43) | PTGS2KDM4ELMNAPTGS1MALT1 | |
| SCHEMBL8423899 | 0.83 | KDM1A (0.43) | PTGS2LMNAKAT6AMALT1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |