Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420848 | 0.91 | PTGS2 (0.46) | AURKALMNAKDM4EKDM1AKAT6A | |
| SCHEMBL8421776 | 0.88 | KDM1A (0.47) | AURKAKDM4EKDM1AKAT6APTGS2 | |
| SCHEMBL8641119 | 0.87 | AURKA (0.46) | AURKAKDM4EKDM1AKAT6APTGS2 | |
| SCHEMBL8421619 | 0.85 | KMO (0.46) | AURKAKDM1APTGS2NPC1MAPT | |
| SCHEMBL8422269 | 0.85 | PGR (0.44) | AURKALMNAKDM1AKAT6APTGS2 | |
| SCHEMBL8420906 | 0.85 | KDM1A (0.46) | AURKAKDM1APTGS2NPC1MAPT | |
| SCHEMBL8422366 | 0.85 | KDM1A (0.46) | AURKAKDM1APTGS2NPC1MAPT | |
| SCHEMBL8421656 | 0.84 | KDM1A (0.42) | AURKAKDM4EKDM1AKAT6APTGS2 | |
| SCHEMBL8422316 | 0.84 | KDM1A (0.44) | AURKAKDM4EKDM1APTGS2NPC1 | |
| SCHEMBL8424131 | 0.83 | KDM1A (0.41) | AURKAKDM1APTGS2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908852-A | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation | G. D. SEARLE & CO. (US) | 1999-06-01 | — | — | US | disclosed |